Database Description

PRKAR1A gene encodes the regulatory subunit type 1-alpha (RI╬▒) of the cAMP-dependent protein kinase (PKA). Inactivating PRKAR1A mutations are known to be responsible for the multiple neoplasia and lentiginosis syndrome Carney complex (CNC). The PRKAR1A Mutation Database has been established to facilitate the characterization of pathogenic variants in PRKAR1A.

Appropriate Data Usage

Information in the database should be used for research purposes only. While every effort has been made to depict accurately the nature of the gene variants, users of the database should treat the reported variants with caution. The data within the database are not intended to be used for the provision of any clinical recommendations.

Data Submission

Data submission will be accepted by using the submission form. Before any submitted data is integrated into the database, it will be examined and edited where necessary by curators of the PRKAR1A database in order to ensure the quality of the input data.

Respecting The Efforts Of Contributing Authors

Any data within the database that has not been published in a periodic journal must be treated as privileged information. Such data should not be disseminated to others without the permission of the contributing author. Any publications arising from the use of PRKAR1A mutation database should cite the database (

User Acknowledgement

In entering this database, you as a user acknowledge having read, understood and are willing to abide by the above stated disclaimer.

New Features In This Release

Initial release.

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